Significantly Mutated Genes

Cancer Selection:

Threshold:
  
Data Type:

DNA-seq + RNA-seq   DNA-seq RNA-seq

   
User Guide:

Retrieve the list of genes that are most significantly mutated in a certain cancer type. Significantly mutated genes (SMGs) were determined by DNDScv.
  • Cancer selection: Select cancer type of interest from the drop-down menu.
  • Threshold: Settings used to filter gene list.
    • FDR Adjusted p-value: Set custom FDR (False Discovery Rate) adjusted p-value (q-value). Return genes with a q-value equal to or lower than threshold.
    • Mutation percentage: Set cut-off for mutation percentage. Mutation percentage was calculated as the number of patients with the mutation divided by the total number of patients examined.
  • Data Type: Select the data type for somatic mutation analysis. Somatic mutations can be detected using either DNA-seq or RNA-seq alone, or by combining the results from both sequencing datasets, referred to as "DNA-seq + RNA-seq".